INTRODUCTION Vaccination for preventable diseases is a high-value healthcare intervention, yet rates remain below US Centers for Disease Control and Prevention (CDC) benchmarks, especially among minorities. The complex American healthcare system is difficult to navigate, contributing to underuse of vaccination. Decreased trust in the system resulting from a history of discrimination further exacerbates low vaccination rates (VR) among African Americans (AA) in particular. Senior centers (SC) are an accessible, trusted venue for AA, presenting an opportunity to increase VR. OBJECTIVE To describe the evolution of three innovative vaccine education models developed in partnership with a nationally accredited Philadelphia SC.